What Is PDRN? A Guide to Salmon PDRN in Korean Skincare
Written by FRANKLY Lab. FRANKLY was founded by former cosmetic R&D researchers from one of Korea's largest beauty companies, and every formula is still developed in-house by our R&D team in Korea.
Quick answer: PDRN (polydeoxyribonucleotide) is a DNA-derived ingredient, most often sourced from salmon, that became popular through Korean dermatology clinics. In skincare, PDRN is used to help skin look plumper, bouncier, more hydrated and more radiant. It suits dull, dry, tired-looking and mature skin, and pairs well with retinol, peptides and hydrating ingredients. Because it is salmon-derived, PDRN skincare is not vegan.
What is PDRN?
PDRN stands for polydeoxyribonucleotide. It is a mix of DNA fragments purified from natural sources, most commonly salmon. On an ingredient list (INCI), PDRN usually appears as Sodium DNA.
PDRN first became well known in Korea through in-clinic skin treatments. Over the past few years it has moved into everyday skincare, where it now shows up in serums, creams, ampoules and masks, often under the name "salmon PDRN" or "salmon DNA".
Why salmon PDRN?
Salmon is the most widely used source of PDRN in skincare. Salmon-derived DNA can be purified to a high level, which is why many formulas highlight both the source (salmon) and the purity of the PDRN raw material.
What does PDRN do for skin?
In cosmetic skincare, PDRN is used to:
- Help skin look plumper and bouncier
- Support the look of firmness and elasticity
- Boost hydration and a healthy, glass-skin glow
- Help skin look and feel comfortable and refreshed, including in at-home routines after professional treatments
PDRN works best alongside supporting ingredients such as niacinamide, adenosine, hyaluronic acid and peptides, and results build with consistent daily use.
Who should use PDRN?
- Skin that looks dull, tired or less bouncy
- Dry or dehydrated skin
- Mature skin concerned with the look of fine lines and loss of firmness
- Anyone who wants a clinic-inspired step in a simple at-home routine
How to use PDRN in your skincare routine
- Cleanse, then use toner.
- Apply your PDRN serum and pat until absorbed.
- Moisturize. At night, you can apply retinol after your PDRN serum.
- Use SPF every morning.
Pairing tips: PDRN works well with retinol, peptides, niacinamide and hyaluronic acid. If you use strong exfoliants (AHA or BHA), use them on different nights from retinol.
After professional treatments (such as microneedling): always follow your practitioner's aftercare advice, and only start skincare once they confirm your skin is ready.
Is PDRN vegan? Is it safe for sensitive skin?
PDRN from salmon is not vegan. Most PDRN serums are lightweight and suitable for sensitive skin, but as with any new product, patch test first. If you have a fish allergy, check with your doctor before using salmon-derived ingredients.
FRANKLY PDRN Bounce Ball Serum
PDRN Bounce Ball Serum is our shake-to-activate take on PDRN. An orange bounce ball holds concentrated 99% Salmon PDRN with salmon egg extract. One shake breaks it into micro-particles that blend into a hydrating essence with niacinamide and adenosine, so every application is freshly mixed.
- 97.5% were satisfied with skin radiance
- 95% were satisfied with skin firmness (deep elasticity)
*Based on a 4-week clinical consumer satisfaction survey of PDRN Bounce Ball Serum & Cream conducted by Human Co., Ltd. Skin Clinical Trial Center, n=40. Individual results may vary.
Looking for a routine? Pair it with Retinol 0.1 Cream in the Mature Skin Duo, with Rice Jelly Toner Pads in the Prep & Plump Duo, or with Closer Serum in the Glass Skin Serum Duo.
PDRN FAQ
What is PDRN in skincare?
PDRN (polydeoxyribonucleotide) is a DNA-derived ingredient, usually from salmon, used to help skin look plumper, more hydrated and more radiant.
What is PDRN called on the ingredient list?
It usually appears as Sodium DNA.
Can I use PDRN with retinol?
Yes. Apply your PDRN serum first, then retinol at night.
Can I use PDRN every day?
Yes. PDRN serums are typically made for morning and night use.
How long does it take to see results?
Skin can feel more hydrated right away. Changes in the look of firmness and radiance build with consistent use over several weeks.